Moving beyond e-journals

Paul Ayris explains to Elspeth Hyams why scholarly communication has moved beyond the debate on e-journals pricing and open access

btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis

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Masses and widths of scalar-isoscalar multi-channel resonances from data analysis

Peculiarities of obtaining parameters for broad multi-channel resonances from data are discussed analyzing the experimental data on processes $\pi\pi\to\pi\pi,K\bar{K}$ in the $I^GJ^{PC}=0^+0^{++}$ channel in a model-independent approach based on analyticity and unitarity and using an uniformization procedure. We show that it is possible to obtain a good description of the $\pi\pi$ scattering data from the threshold to 1.89 GeV with parameters of resonances cited in the PDG tables as preferred. However, in this case, first, representation of the $\pi\pi$ background is unsatisfactory; second, the data on the coupled process $\pi\pi\to K\bar{K}$ are not well described even qualitatively above 1.15 GeV when using the resonance parameters from the only $\pi\pi$ scattering analysis. The combined analysis of these coupled processes is needed, which is carried out satisfactorily. Then both above-indicated flaws, related to the analysis of solely the $\pi\pi$-scattering, are cured. The most remarkable change of parameters with respect to the values of only $\pi\pi$ scattering analysis appears for the mass of the $f_0 (600)$ which is now in some accordance with the Weinberg prediction on the basis of mended symmetry and with an analysis using the large-$N_c$ consistency conditions between the unitarization and resonance saturation. The obtained $\pi\pi$-scattering length $a_0^0$ in case when we restrict to the analysis of the $\pi\pi$ scattering or consider so-called A-solution (with a lower mass and width of $f_0(600)$ meson) agrees well with prediction of chiral perturbation theory (ChPT) and with data extracted at CERN by the NA48/2 Collaboration from the analysis of the $K_{e4}$ decay and by the DIRAC Collaboration from the measurement of the $\pi^+\pi^-$ lifetime.Comment: 21 pages, 3 figures, 6 table

A low-lying scalar meson nonet in a unitarized meson model

A unitarized nonrelativistic meson model which is successful for the description of the heavy and light vector and pseudoscalar mesons yields, in its extension to the scalar mesons but for the same model parameters, a complete nonet below 1 GeV. In the unitarization scheme, real and virtual meson-meson decay channels are coupled to the quark-antiquark confinement channels. The flavor-dependent harmonic-oscillator confining potential itself has bound states epsilon(1.3 GeV), S(1.5 GeV), delta(1.3 GeV), kappa(1.4 GeV), similar to the results of other bound-state qqbar models. However, the full coupled-channel equations show poles at epsilon(0.5 GeV), S(0.99 GeV), delta(0.97 GeV), kappa(0.73 GeV). Not only can these pole positions be calculated in our model, but also cross sections and phase shifts in the meson-scattering channels, which are in reasonable agreement with the available data for pion-pion, eta-pion and Kaon-pion in S-wave scattering.Comment: A slightly revised version of Zeitschrift fuer Physik C30, 615 (1986

Second Cluster Integral and Excluded Volume Effects for the Pion Gas

The quantum mechanical formula for Mayer's second cluster integral for the gas of relativistic particles with hard-core interaction is derived. The proper pion volume calculated with quantum mechanical formula is found to be an order of magnitude larger than its classical evaluation. The second cluster integral for the pion gas is calculated in quantum mechanical approach with account for both attractive and hard-core repulsive interactions. It is shown that, in the second cluster approximation, the repulsive pion-pion-interactions as well as the finite width of resonances give important but almost canceling contributions. In contrast, an appreciable deviation from the ideal gas of pions and pion resonances is observed beyond the second cluster approximation in the framework of the Van der Waals excluded-volume model.Comment: 29 pages, Latex, 9 PS-figure

Infliximab in paediatric inflammatory bowel disease

AbstractInfliximab has been widely used in paediatric Crohn's disease, mainly in luminal and fistulous disease refractory to standard treatment and for extraintestinal manifestations. Moreover, there is growing experience with its use in refractory ulcerative colitis. Infliximab has shown similar efficacy and safety in children as in adult population. It is postulated that its early use in paediatric inflammatory bowel disease, as a bridging treatment until the onset of action of other immunomodulators, could reduce the use of steroids and change the natural history of the disease as well. The effect of infliximab on mucosal healing could also contribute to the normal growth and sexual maturation in these patients

S-wave Meson-Meson Scattering from Unitarized U(3) Chiral Lagrangians

An investigation of the s-wave channels in meson-meson scattering is performed within a U(3) chiral unitary approach. Our calculations are based on a chiral effective Lagrangian which includes the eta' as an explicit degree of freedom and incorporates important features of the underlying QCD Lagrangian such as the axial U(1) anomaly. We employ a coupled channel Bethe-Salpeter equation to generate poles from composed states of two pseudoscalar mesons. Our results are compared with experimental phase shifts up to 1.5 GeV and effects of the eta' within this scheme are discussed.Comment: 18 pages, 6 figure